Original title: Reprogramming of cardiac phosphoproteome, proteome and transcriptome confers resilience to chronic adenylyl cyclase-driven stress
Authors: Jia-Hua Qu,Khalid Chakir,Kirill V. Tarasov,Daniel R. Riordon,Maria Grazia Perino,Allwin Jennifa Silvester,Edward G. Lakatta
In this article, researchers conducted a study to understand the adaptive mechanisms that occur in response to the overexpression of adenylyl cyclase type 8 (TGAC8) in the heart. They analyzed the phosphorylation of proteins in the left ventricle of adult TGAC8 mice and compared it to wild-type mice. The results showed that there were significant changes in protein phosphorylation in the TGAC8 mice, indicating the activation of stress-response pathways and the involvement of various kinases and phosphatases. The researchers also found that the hyper-phosphorylated transcription factors in the TGAC8 mice were associated with increased mRNA transcription, immune responses, and metabolic pathways. By integrating the phosphoproteome with the transcriptome and proteome, the researchers were able to understand the coordinated regulation of cardiac performance and adaptive protection at different levels. This study provides insights into potential therapeutic targets for enhancing heart adaptivity and maintaining heart function while preventing dysfunction.
Original article: https://www.biorxiv.org/content/10.1101/2022.04.29.488779v11