Can Optogenetics Identify and Control GABAergic Interneuron Subtypes In Vivo?

Original title: In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes

Authors: Lisa Roux (NYU Langone Medical Center), Eran Stark (NYU Langone Medical Center), Lucas Sjulson (NYU Langone Medical Center), György Buzsáki (NYU Langone Medical Center)

The article explores how identifying and manipulating distinct GABAergic interneuron types in active animals aids in understanding their role in brain circuits and behavior. By combining optogenetics with extensive neuronal recordings, researchers can pinpoint and influence specific interneuron groups to analyze intact circuits. Precise light delivery, synchronized with electrophysiological recording, is crucial. This approach enables focused activation or inhibition of neurons in precise temporal patterns or a closed-loop fashion, unlocking avenues for addressing new inquiries. Recent advancements showcase the effectiveness of this technique in studying interneurons, offering a powerful tool for exploring the complexities of brain circuitry.

Original article: https://arxiv.org/abs/2311.10410